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Systemic Mastocytosis Summary

Description: A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.

Also Known As: Mastocytosis, Systemic; Aggressive Systemic Mastocytosis; Indolent Systemic Mastocytosis; Aggressive Systemic Mastocytoses; Indolent Systemic Mastocytoses Show All >>

Networked: 467 relevant articles (34 outcomes, 34 trials/studies) for this Disease

Key Drugs and Agents for Systemic Mastocytosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. imatinib (Gleevec) : 7 outcomes 2 studies in 46 results : FDA 3
  2. Venoms : 4 outcomes 2 studies in 12 results : IBA
  3. Interferon-alpha (Interferon Alfa) : 4 outcomes 1 study in 23 results : FDA 2
  4. Cromolyn Sodium (Cromoglicic Acid) : 3 outcomes 1 study in 10 results : FDA 26 Generic
  5. Protein-Tyrosine Kinases (Tyrosine Kinase) : 2 outcomes 1 study in 23 results : IBA
  6. dasatinib (BMS 354825) : 2 outcomes 1 study in 8 results : FDA 2
  7. omalizumab (Xolair) : 2 outcomes 1 study in 8 results : FDA 2
  8. Cladribine : 2 outcomes in 9 results : FDA 3 Generic
  9. Tryptases (Tryptase) : 1 outcome 1 study in 55 results : IBA
  10. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib) : 1 outcome 1 study in 4 results : FDA 1
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Diseases Related to Systemic Mastocytosis

  1. Anaphylaxis (Anaphylactic Shock)
  2. Mastocytosis (Mast-Cell Disease)
  3. Hypersensitivity (Allergy)
  4. Urticaria Pigmentosa
  5. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
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Key Therapies for Systemic Mastocytosis

Efficacy Chart >>
  1. Immunotherapy : 5 outcomes 2 studies in 11 results
  2. Drug Therapy (Chemotherapy) : 2 outcomes in 7 results
  3. Splenectomy : 1 outcome in 4 results
  4. Combination Drug Therapy (Combination Chemotherapy) : 1 outcome in 2 results
  5. Stem Cell Transplantation : 1 outcome in 1 result
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