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Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) Summary

Description: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).

Also Known As: Lymphoma, Mantle Cell; Lymphoma, Mantle-Cell; Diffuse Lymphocytic Lymphoma, Poorly-Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly Differentiated; Centrocytic Small-Cell Lymphoma Show All >>

Networked: 1519 relevant articles (121 outcomes, 239 trials/studies) for this Disease

Key Drugs and Agents for Mantle-Cell Lymphoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. rituximab (Mabthera) : 39 outcomes 67 studies in 233 results : FDA 3
  2. bortezomib (Velcade) : 14 outcomes 31 studies in 186 results : FDA 1
  3. Cyclophosphamide (Cytoxan) : 8 outcomes 16 studies in 55 results : FDA 10 Generic
  4. bendamustine : 7 outcomes 20 studies in 43 results : FDA 2
  5. lenalidomide (CC 5013) : 7 outcomes 12 studies in 40 results : FDA 2
  6. Cytarabine (Cytosar-U) : 7 outcomes 7 studies in 36 results : FDA 13 Generic
  7. Vincristine (Oncovin) : 6 outcomes 12 studies in 42 results : FDA 17 Generic
  8. Doxorubicin (Adriamycin) : 6 outcomes 10 studies in 38 results : FDA 12 Generic
  9. Proteasome Endopeptidase Complex (Proteasome) : 6 outcomes 3 studies in 100 results : IBA
  10. Prednisone (Sone) : 5 outcomes 10 studies in 26 results : FDA 119 Generic
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Diseases Related to Mantle-Cell Lymphoma

  1. Lymphoma (Lymphomas)
  2. Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
  3. Non-Hodgkin Lymphoma (Lymphosarcoma)
  4. Neoplasms (Cancer)
  5. Multiple Myeloma
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Key Therapies for Mantle-Cell Lymphoma

Efficacy Chart >>
  1. Stem Cell Transplantation : 25 outcomes 23 studies in 98 results
  2. Drug Therapy (Chemotherapy) : 24 outcomes 24 studies in 172 results
  3. Transplants (Transplant) : 4 outcomes 6 studies in 35 results
  4. Transplantation (Transplant Recipients) : 4 outcomes 6 studies in 23 results
  5. Autologous Transplantation : 4 outcomes 3 studies in 15 results
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