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Isaacs Syndrome
(Neuromyotonia)
Summary
Description:
A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Also Known As:
Neuromyotonia; Isaacs-Mertens Syndrome; Pseudomyotonia; Acquired Neuromyotonia; Continuous Muscle Activity Syndrome Show All >>
Networked: 194
relevant articles (8 outcomes,
4 trials/studies)
for this Disease
Key Drugs and Agents for Isaacs Syndrome
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
-
Antibodies
:
2 outcomes 2 studies in 66 results
: IBA
-
Carbamazepine (Tegretol)
:
2 outcomes 2 studies in 13 results
:
FDA 24
Generic
-
Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)
:
1 outcome in 56 results
: IBA
-
Autoantibodies
:
1 outcome in 24 results
: IBA
-
Immunoglobulin G (IgG)
:
1 outcome in 4 results
: IBA
-
Methylprednisolone
:
1 outcome in 2 results
:
FDA 18
Generic
-
Anticonvulsants (Antiepileptic Drugs)
:
1 outcome in 2 results
: IBA
-
gabapentin (Neurontin)
:
1 outcome in 2 results
:
FDA 37
Generic
-
Cyclophosphamide (Cytoxan)
:
1 outcome in 1 result
:
FDA 10
Generic
-
Potassium Channels (Potassium Channel)
:
1 study in 20 results
: IBA
Show All >>
Diseases Related to Isaacs Syndrome
-
Isaacs Syndrome (Neuromyotonia)
-
Thymoma (Thymic Carcinoma)
-
Constipation
-
Myokymia
-
Myoclonus (Nocturnal Myoclonus)
Show All >>
Key Therapies for Isaacs Syndrome
Efficacy Chart >>
-
Plasmapheresis
:
2 outcomes in 5 results
-
Plasma Exchange
:
9 results
-
Anesthesia
:
4 results
-
Thymectomy
:
3 results
-
Radiotherapy
:
3 results
Show All >>
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