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Paraneoplastic Cerebellar Degeneration Summary

Description: Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

Also Known As: Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndrome, Paraneoplastic; Paraneoplastic Cerebellar Syndrome; Anti Yo Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndromes, Paraneoplastic Show All >>

Networked: 185 relevant articles (6 outcomes, 10 trials/studies) for this Disease

Key Drugs and Agents for Paraneoplastic Cerebellar Degeneration

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Antibodies : 2 outcomes 6 studies in 90 results : IBA
  2. Autoantibodies : 1 outcome in 20 results : IBA
  3. metabotropic glutamate receptor type 1 : 1 outcome in 1 result : IBA
  4. Antigens : 4 studies in 38 results : IBA
  5. Calcium Channels (Calcium Channel) : 1 study in 9 results : IBA
  6. Complementary DNA (cDNA) : 1 study in 6 results : IBA
  7. HLA-A2 Antigen (HLA A2 Antigen) : 1 study in 2 results : IBA
  8. Surface Antigens (Surface Antigen) : 1 study in 2 results : IBA
  9. Epitopes : 1 study in 2 results : IBA
  10. Peptides : 1 study in 1 result : IBA
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Diseases Related to Paraneoplastic Cerebellar Degeneration

  1. Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome)
  2. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
  3. Neoplasms (Cancer)
  4. Hodgkin Disease (Hodgkin's Disease)
  5. Paraneoplastic Syndromes (Paraneoplastic Syndrome)
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Key Therapies for Paraneoplastic Cerebellar Degeneration

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 3 outcomes in 7 results
  2. Plasmapheresis : 1 outcome in 5 results
  3. Immunomodulation : 1 outcome in 1 result
  4. Ovariectomy (Oophorectomy) : 2 results
  5. Plasma Exchange : 1 result
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