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Lafora Disease Summary

Description: A form of stimulus sensitive myoclonic epilepsy inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110)

Also Known As: Epilepsy Progressive Myoclonic 2; Lafora Body Disease; Lafora Body Disease, Late Onset; Lafora Body Disorder; Lafora Progressive Myoclonic Epilepsy Show All >>

Networked: 127 relevant articles (2 outcomes, 6 trials/studies) for this Disease

Key Drugs and Agents for Lafora Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. polyglucosan : 1 outcome in 36 results : IBA
  2. Proteins (Proteins, Gene) : 1 outcome in 16 results : IBA
  3. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase) : 1 outcome in 10 results : IBA
  4. Ubiquitin : 1 outcome in 8 results : IBA
  5. perampanel : 1 outcome in 2 results : IBA
  6. Glycogen : 3 studies in 48 results : IBA
  7. Carbohydrates : 1 study in 4 results : IBA
  8. Glycogen Synthase (Synthase I) : 1 study in 3 results : IBA
  9. Immune Sera (Antisera) : 1 study in 2 results : IBA
  10. Enzymes : 1 study in 2 results : IBA
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Diseases Related to Lafora Disease

  1. Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy)
  2. Seizures (Seizure)
  3. Glycogen Storage Disease (Glycogenosis)
  4. Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy)
  5. Neurodegenerative Diseases (Neurodegenerative Disease)
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Key Therapies for Lafora Disease

Efficacy Chart >>
  1. Vagus Nerve Stimulation : 1 result
  2. Ketogenic Diet : 1 result
  3. Therapeutics : 1 result
  4. Subcutaneous Injections : 1 result

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