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P-Glycoprotein Summary

Description: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Also Known As: ATP-Binding Cassette, Sub-Family B, Member 1; P-gp; PGY-1 Protein; P Glycoprotein; PGY 1 Protein Show All >>

Networked: 5596 relevant articles (205 outcomes, 830 trials/studies) for this Bio-Agent

Key Diseases for which P-Glycoprotein is Relevant

  1. Neoplasms (Cancer) : 104 outcomes 228 studies in 2452 results
  2. Breast Neoplasms (Breast Cancer) : 19 outcomes 162 studies in 964 results
  3. Alzheimer Disease (Alzheimer's Disease) : 8 outcomes 5 studies in 46 results
  4. Leukemia : 7 outcomes 44 studies in 284 results
  5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia) : 7 outcomes 22 studies in 160 results
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Drugs Related to P-Glycoprotein

  1. P-Glycoprotein
  2. Paclitaxel (Taxol)
  3. Doxorubicin (Adriamycin)
  4. Carbon Monoxide
  5. Amyloid (Amyloid Fibrils)
  6. Proteins (Proteins, Gene)
  7. Adenosine Triphosphate (ATP)
  8. Multidrug Resistance-Associated Proteins
  9. Daunorubicin (Cerubidine)
  10. Small Interfering RNA (siRNA)
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Therapies Related to P-Glycoprotein

  1. Drug Therapy (Chemotherapy)
  2. Remission Induction
  3. Therapeutics
  4. Heterologous Transplantation (Xenotransplantation)
  5. Combination Drug Therapy (Combination Chemotherapy)
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