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Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome) Summary

Description: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.

Also Known As: Goodpasture's Syndrome; Goodpasture Syndrome; Anti GBM Disease; Syndrome, Goodpasture's; Lung Purpura with Nephritis Show All >>

Networked: 663 relevant articles (21 outcomes, 43 trials/studies) for this Disease

Key Drugs and Agents for Anti-Glomerular Basement Membrane Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. antiglomerular basement membrane antibody : 4 outcomes 8 studies in 117 results : IBA
  2. Cyclophosphamide (Cytoxan) : 3 outcomes 1 study in 18 results : FDA 10 Generic
  3. Antibodies : 2 outcomes 6 studies in 148 results : IBA
  4. Antineutrophil Cytoplasmic Antibodies (ANCA) : 2 outcomes 3 studies in 69 results : IBA
  5. Steroids : 2 outcomes in 7 results : IBA
  6. Immunoglobulin G (IgG) : 1 outcome 5 studies in 43 results : IBA
  7. Idiopathic pulmonary hemosiderosis : 1 outcome 1 study in 21 results : IBA
  8. Antigen-Antibody Complex (Immune Complex) : 1 outcome in 31 results : IBA
  9. Immunoglobulin A (IgA) : 1 outcome in 17 results : IBA
  10. alemtuzumab (Campath) : 1 outcome in 3 results : FDA 2
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Diseases Related to Anti-Glomerular Basement Membrane Disease

  1. Glomerulonephritis
  2. Systemic Lupus Erythematosus (Libman-Sacks Disease)
  3. Hemorrhage
  4. Myasthenia Gravis
  5. Vasculitis (Vasculitides)
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Key Therapies for Anti-Glomerular Basement Membrane Disease

Efficacy Chart >>
  1. Plasmapheresis : 5 outcomes 2 studies in 45 results
  2. Plasma Exchange : 2 outcomes in 35 results
  3. Blood Component Removal (Apheresis) : 2 outcomes in 6 results
  4. Transplants (Transplant) : 1 outcome in 26 results
  5. Tissue Therapy (Cell Therapy) : 1 outcome in 1 result
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