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Endothelin-1 (Endothelin 1) Summary

Description: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)

Also Known As: Endothelin 1; Big Endothelin; Big Endothelin-1; ET-1 (Endothelin-1); Endothelin Type 1 Show All >>

Networked: 4846 relevant articles (89 outcomes, 654 trials/studies) for this Bio-Agent

Key Diseases for which Endothelin-1 is Relevant

  1. Pulmonary Hypertension (Ayerza Syndrome) : 12 outcomes 46 studies in 263 results
  2. Heart Failure : 12 outcomes 41 studies in 297 results
  3. Hypertension (High Blood Pressure) : 5 outcomes 61 studies in 516 results
  4. Cardiomegaly (Heart Hypertrophy) : 5 outcomes 10 studies in 79 results
  5. Reperfusion Injury : 5 outcomes 9 studies in 59 results
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Drugs Related to Endothelin-1

  1. Nitric Oxide (Nitrogen Monoxide)
  2. Endothelin Receptors (Endothelin Receptor)
  3. bosentan (Tracleer)
  4. Endothelin-1 (Endothelin 1)
  5. Interleukin-6 (Interleukin 6)
  6. Biological Markers (Surrogate Marker)
  7. Idiopathic pulmonary hypertension
  8. Pravastatin (Pravachol)
  9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  10. Messenger RNA (mRNA)
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Therapies Related to Endothelin-1

  1. Liver Transplantation
  2. Continuous Positive Airway Pressure
  3. Cell Transplantation
  4. Cardiopulmonary Resuscitation (CPR)
  5. Transplants (Transplant)
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