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Leukostasis Summary

Description: Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.

Also Known As: Leukostases; Leukostasis Syndromes; Syndrome, Leukostasis; Syndromes, Leukostasis; Leukostasis Syndrome

Networked: 241 relevant articles (18 outcomes, 28 trials/studies) for this Disease

Key Drugs and Agents for Leukostasis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Retinaldehyde (Retinal) : 3 outcomes 16 studies in 88 results : IBA
  2. Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1) : 3 outcomes 3 studies in 28 results : IBA
  3. Nitric Oxide Synthase (NO Synthase) : 2 outcomes 1 study in 5 results : IBA
  4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor) : 2 outcomes in 9 results : IBA
  5. PPAR gamma : 2 outcomes in 3 results : IBA
  6. NAD (NADH) : 2 outcomes in 2 results : IBA
  7. Superoxides (Superoxide) : 1 outcome 1 study in 11 results : IBA
  8. P-Selectin : 1 outcome 1 study in 2 results : IBA
  9. DNA (Deoxyribonucleic Acid) : 1 outcome 1 study in 2 results : IBA
  10. Carrier Proteins (Binding Protein) : 1 outcome 1 study in 2 results : IBA
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Diseases Related to Leukostasis

  1. Diabetic Retinopathy (Retinopathy, Diabetic)
  2. Hypertension (High Blood Pressure)
  3. Inflammation
  4. Leukemia
  5. Thrombosis (Thrombus)
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Key Therapies for Leukostasis

Efficacy Chart >>
  1. Transplants (Transplant) : 2 outcomes in 4 results
  2. Renal Dialysis (Hemodialysis) : 1 study in 9 results
  3. Intravenous Infusions : 1 study in 1 result
  4. Drug Therapy (Chemotherapy) : 12 results
  5. Blood Component Removal (Apheresis) : 4 results
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