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Protein S Deficiency (Deficiency, Protein S) Summary

Description: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

Also Known As: Deficiency, Protein S; Deficiencies, Protein S; Protein S Deficiencies

Networked: 693 relevant articles (5 outcomes, 36 trials/studies) for this Disease

Key Drugs and Agents for Protein S Deficiency

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Protein C : 2 outcomes 18 studies in 262 results : IBA
  2. Protein S : 1 outcome 10 studies in 135 results : IBA
  3. Antithrombin III : 1 outcome 3 studies in 48 results : IBA
  4. Warfarin (Coumadin) : 1 outcome 1 study in 26 results : FDA 21 Generic
  5. Thrombin : 1 outcome 1 study in 11 results : FDA 2
  6. Heparin (Liquaemin) : 1 outcome in 18 results : FDA 74 Generic
  7. Vitamin K : 1 outcome in 7 results : FDA 6
  8. Tissue Plasminogen Activator (Alteplase) : 1 outcome in 5 results : FDA 2
  9. Complement C4b-Binding Protein : 1 outcome in 4 results : IBA
  10. Proteins (Proteins, Gene) : 1 outcome in 4 results : IBA
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Diseases Related to Protein S Deficiency

  1. Thrombosis (Thrombus)
  2. Necrosis
  3. Thrombophilia
  4. Antithrombin III Deficiency
  5. Protein C Deficiency
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Key Therapies for Protein S Deficiency

Efficacy Chart >>
  1. Catheters : 1 study in 4 results
  2. Stents : 1 study in 2 results
  3. Coronary Artery Bypass (Coronary Artery Bypass Surgery) : 8 results
  4. Transplants (Transplant) : 7 results
  5. Cesarean Section (Caesarean Section) : 6 results
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