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Hypereosinophilic Syndrome (Loeffler Endocarditis) Summary

Description: A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of eosinophils in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs. It is often referred to as idiopathic.

Also Known As: Loeffler Endocarditis; Idiopathic Hypereosinophilic Syndrome; Endocarditis, Loeffler; Leukemia, Eosinophilic; Endocarditis, Loefflers Show All >>

Networked: 619 relevant articles (54 outcomes, 30 trials/studies) for this Disease

Key Drugs and Agents for Hypereosinophilic Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. imatinib (Gleevec) : 32 outcomes 6 studies in 143 results : FDA 3
  2. Interferon-alpha (Interferon Alfa) : 5 outcomes 1 study in 32 results : FDA 2
  3. mepolizumab : 4 outcomes 4 studies in 22 results : IBA
  4. Prednisone (Sone) : 3 outcomes in 9 results : FDA 119 Generic
  5. Antibodies : 3 outcomes in 9 results : IBA
  6. Protein-Tyrosine Kinases (Tyrosine Kinase) : 2 outcomes 2 studies in 42 results : IBA
  7. Interleukin-5 (Interleukin 5) : 2 outcomes 1 study in 35 results : IBA
  8. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor) : 2 outcomes in 25 results : IBA
  9. Phosphotransferases (Kinase) : 2 outcomes in 15 results : IBA
  10. Cyclosporine (Ciclosporin) : 2 outcomes in 8 results : FDA 20 Generic
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Diseases Related to Hypereosinophilic Syndrome

  1. Hypereosinophilic Syndrome (Loeffler Endocarditis)
  2. Eosinophilia
  3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
  4. Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
  5. Neoplasms (Cancer)
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Key Therapies for Hypereosinophilic Syndrome

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 1 outcome in 5 results
  2. Stem Cell Transplantation : 1 outcome in 4 results
  3. Transplants (Transplant) : 1 outcome in 3 results
  4. Off-Label Use : 1 outcome in 1 result
  5. Biological Therapy : 1 outcome in 1 result
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