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Kleine-Levin Syndrome
(Syndrome, Kleine-Levin)
Summary
Description:
A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
Also Known As:
Syndrome, Kleine-Levin; Familial Hibernation (Kleine-Levin) Syndrome; Familial Kleine-Levin Syndrome; Kleine-Levin Hibernation Syndrome; Kleine-Levin-Critchley Syndrome Show All >>
Networked: 61
relevant articles (5 outcomes,
3 trials/studies)
for this Disease
Key Drugs and Agents for Kleine-Levin Syndrome
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
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Lithium
:
2 outcomes 2 studies in 13 results
: IBA
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Lithium Carbonate (Eskalith)
:
1 outcome in 4 results
:
FDA 29
Generic
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Carbamazepine (Tegretol)
:
1 outcome in 4 results
:
FDA 24
Generic
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gabapentin (Neurontin)
:
1 outcome in 1 result
:
FDA 37
Generic
-
Antidepressive Agents (Antidepressants)
:
1 study in 1 result
: IBA
-
Anticonvulsants (Antiepileptic Drugs)
:
1 study in 1 result
: IBA
-
tranilast (N 5')
:
1 study in 1 result
: IBA
-
Valproic Acid (Valproate, Semisodium)
:
4 results
:
FDA 51
Generic
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modafinil (armodafinil)
:
4 results
:
FDA 10
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orexins (orexin)
:
3 results
: IBA
Show All >>
Diseases Related to Kleine-Levin Syndrome
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Epilepsy (Aura)
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Disorders of Excessive Somnolence (Hypersomnia)
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Kleine-Levin Syndrome (Syndrome, Kleine-Levin)
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Prader-Willi Syndrome (Syndrome, Prader-Willi)
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Narcolepsy
Show All >>
Key Therapies for Kleine-Levin Syndrome
Efficacy Chart >>
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Drug Therapy (Chemotherapy)
:
1 study in 1 result
-
Phototherapy (Light Therapy)
:
1 result
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