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Kleine-Levin Syndrome (Syndrome, Kleine-Levin) Summary

Description: A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

Also Known As: Syndrome, Kleine-Levin; Familial Hibernation (Kleine-Levin) Syndrome; Familial Kleine-Levin Syndrome; Kleine-Levin Hibernation Syndrome; Kleine-Levin-Critchley Syndrome Show All >>

Networked: 61 relevant articles (5 outcomes, 3 trials/studies) for this Disease

Key Drugs and Agents for Kleine-Levin Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Lithium : 2 outcomes 2 studies in 13 results : IBA
  2. Lithium Carbonate (Eskalith) : 1 outcome in 4 results : FDA 29 Generic
  3. Carbamazepine (Tegretol) : 1 outcome in 4 results : FDA 24 Generic
  4. gabapentin (Neurontin) : 1 outcome in 1 result : FDA 37 Generic
  5. Antidepressive Agents (Antidepressants) : 1 study in 1 result : IBA
  6. Anticonvulsants (Antiepileptic Drugs) : 1 study in 1 result : IBA
  7. tranilast (N 5') : 1 study in 1 result : IBA
  8. Valproic Acid (Valproate, Semisodium) : 4 results : FDA 51 Generic
  9. modafinil (armodafinil) : 4 results : FDA 10
  10. orexins (orexin) : 3 results : IBA
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Diseases Related to Kleine-Levin Syndrome

  1. Epilepsy (Aura)
  2. Disorders of Excessive Somnolence (Hypersomnia)
  3. Kleine-Levin Syndrome (Syndrome, Kleine-Levin)
  4. Prader-Willi Syndrome (Syndrome, Prader-Willi)
  5. Narcolepsy
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Key Therapies for Kleine-Levin Syndrome

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 1 study in 1 result
  2. Phototherapy (Light Therapy) : 1 result

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