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Kleine-Levin Syndrome (Syndrome, Kleine-Levin) Summary

Description: A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

Also Known As: Syndrome, Kleine-Levin; Familial Hibernation (Kleine-Levin) Syndrome; Familial Kleine-Levin Syndrome; Kleine-Levin Hibernation Syndrome; Kleine-Levin-Critchley Syndrome Show All >>

Networked: 61 relevant articles (5 outcomes, 3 trials/studies) for this Disease

Key Drugs and Agents for Kleine-Levin Syndrome

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Drugs and Important Biological Agents (IBA) related to treatments:

Lithium : 2 outcomes 2 studies in 13 results : IBA
Lithium Carbonate (Eskalith) : 1 outcome in 4 results : FDA 29 Generic
Carbamazepine (Tegretol) : 1 outcome in 4 results : FDA 24 Generic
gabapentin (Neurontin) : 1 outcome in 1 result : FDA 37 Generic
Antidepressive Agents (Antidepressants) : 1 study in 1 result : IBA
Anticonvulsants (Antiepileptic Drugs) : 1 study in 1 result : IBA
tranilast (N 5') : 1 study in 1 result : IBA
Valproic Acid (Valproate, Semisodium) : 4 results : FDA 51 Generic
modafinil (armodafinil) : 4 results : FDA 10
orexins (orexin) : 3 results : IBA

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Diseases Related to Kleine-Levin Syndrome

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Key Therapies for Kleine-Levin Syndrome

Efficacy Chart >>