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Apolipoprotein A-I (Apolipoprotein A1) Summary

Description: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

Also Known As: Apolipoprotein A1; Apo A-I; Apolipoprotein AI; Apo A-1; ApoA-I Show All >>

Networked: 2703 relevant articles (107 outcomes, 385 trials/studies) for this Bio-Agent

Key Diseases for which Apolipoprotein A-I is Relevant

  1. Atherosclerosis : 31 outcomes 76 studies in 463 results
  2. Inflammation : 12 outcomes 11 studies in 135 results
  3. Coronary Artery Disease (Coronary Atherosclerosis) : 5 outcomes 26 studies in 181 results
  4. Cardiovascular Diseases (Cardiovascular Disease) : 5 outcomes 22 studies in 137 results
  5. Vascular Diseases (Vascular Disease) : 5 outcomes 5 studies in 35 results
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Drugs Related to Apolipoprotein A-I

  1. Apolipoprotein A-I (Apolipoprotein A1)
  2. Lipoproteins (Lipoprotein)
  3. Cholesterol
  4. HDL Cholesterol
  5. Apolipoproteins
  6. Apolipoproteins B (ApoB)
  7. LDL Cholesterol
  8. Triglycerides (Triacylglycerol)
  9. LDL Receptors (LDL Receptor)
  10. Apoproteins
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Therapies Related to Apolipoprotein A-I

  1. Aftercare (After-Treatment)
  2. Ligation
  3. Diet Therapy (Therapy, Diet)
  4. Renal Dialysis (Hemodialysis)
  5. Drug Therapy (Chemotherapy)
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