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Endothelins (Endothelin) Summary

Description: 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.

Also Known As: Endothelin; Vasoconstrictor Factors, Endothelium-Derived; Endothelium-Derived Vasoconstrictor Factors

Networked: 3957 relevant articles (107 outcomes, 545 trials/studies) for this Bio-Agent

Key Diseases for which Endothelins is Relevant

  1. Pulmonary Hypertension (Ayerza Syndrome) : 14 outcomes 19 studies in 173 results
  2. Heart Failure : 13 outcomes 49 studies in 344 results
  3. Hypertension (High Blood Pressure) : 9 outcomes 69 studies in 583 results
  4. Acute Kidney Injury (Acute Renal Failure) : 4 outcomes 3 studies in 57 results
  5. Anoxia (Hypoxia) : 3 outcomes 30 studies in 185 results
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Drugs Related to Endothelins

  1. bosentan (Tracleer)
  2. Endothelin Receptors (Endothelin Receptor)
  3. Epoprostenol (Prostacyclin)
  4. Angiotensin II
  5. Renin
  6. cyclo(Trp-Asp-Pro-Val-Leu)
  7. Endothelins (Endothelin)
  8. TAK 044
  9. tezosentan
  10. N- (5- (4- bromophenyl)- 6- (2- (5- bromopyrimidin- 2- yloxy)ethoxy)pyrimidin- 4- yl)- N'- propylaminosulfonamide
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Therapies Related to Endothelins

  1. Transplants (Transplant)
  2. Aftercare (After-Treatment)
  3. Lung Transplantation
  4. Ligation
  5. Castration
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