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Transforming Growth Factor beta (TGF-beta) Summary

Description: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Also Known As: TGF-beta; Milk Growth Factor; TGFbeta; Bone Derived Transforming Growth Factor; Factor, Milk Growth Show All >>

Networked: 11179 relevant articles (280 outcomes, 1302 trials/studies) for this Bio-Agent

Key Diseases for which Transforming Growth Factor beta is Relevant

  1. Neoplasms (Cancer) : 55 outcomes 203 studies in 2439 results
  2. Fibrosis (Cirrhosis) : 45 outcomes 116 studies in 1452 results
  3. Inflammation : 19 outcomes 35 studies in 619 results
  4. Necrosis : 11 outcomes 34 studies in 383 results
  5. Neoplasm Metastasis (Metastasis) : 11 outcomes 28 studies in 391 results
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Drugs Related to Transforming Growth Factor beta

  1. Transforming Growth Factor beta (TGF-beta)
  2. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  3. Cytokines
  4. Interleukin-10 (Interleukin 10)
  5. Collagen
  6. Messenger RNA (mRNA)
  7. Transforming Growth Factor beta1 (TGF beta 1)
  8. Transforming Growth Factors (Transforming Growth Factor)
  9. Interleukin-2 (IL2)
  10. Bleomycin (Blenoxane)
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Therapies Related to Transforming Growth Factor beta

  1. Drug Therapy (Chemotherapy)
  2. Transplants (Transplant)
  3. Vitrectomy
  4. Immunotherapy
  5. Heterologous Transplantation (Xenotransplantation)
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