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Granulocyte-Macrophage Colony-Stimulating Factor
(GM-CSF)
Summary
Description:
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Also Known As:
GM-CSF; CSF-2; Colony Stimulating Factor, Granulocyte Macrophage; TC-GM-CSF; Tumor-Cell Human GM Colony-Stimulating Factor Show All >>
Networked: 6186
relevant articles (478 outcomes,
1092 trials/studies)
for this Bio-Agent
Key Diseases for which Granulocyte-Macrophage Colony-Stimulating Factor is
Relevant
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Neoplasms (Cancer)
:
147 outcomes 251 studies in 1474 results
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Infection
:
47 outcomes 59 studies in 559 results
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Neutropenia
:
40 outcomes 57 studies in 342 results
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Melanoma (Melanoma, Malignant)
:
16 outcomes 76 studies in 272 results
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Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
:
13 outcomes 44 studies in 242 results
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Drugs Related to Granulocyte-Macrophage Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
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Granulocyte Colony-Stimulating Factor (G-CSF)
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Interleukin-2 (IL2)
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Cytokines
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Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
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Vaccines
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Interleukin-12 (IL 12)
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Interleukin-3 (Interleukin 3)
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Antigens
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Cytarabine (Cytosar-U)
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Therapies Related to Granulocyte-Macrophage Colony-Stimulating Factor
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Drug Therapy (Chemotherapy)
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Immunotherapy
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Radiotherapy
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Bone Marrow Transplantation (Transplantation, Bone Marrow)
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Aftercare (After-Treatment)
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