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Spinal Dysraphism (Spina Bifida) Summary

Description: Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)

Also Known As: Spina Bifida; Rachischisis; Schistorrhachis; Spinal Dysraphia; Bifida, Spina Show All >>

Networked: 1187 relevant articles (31 outcomes, 119 trials/studies) for this Disease

Key Drugs and Agents for Spinal Dysraphism

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Folic Acid (Vitamin M) : 8 outcomes 29 studies in 186 results : FDA 50 Generic
  2. Latex : 4 outcomes 18 studies in 149 results : IBA
  3. Immunoglobulin E (IgE) : 2 outcomes 6 studies in 53 results : IBA
  4. Antibodies : 1 outcome 2 studies in 20 results : IBA
  5. Inositol (Myoinositol) : 1 outcome 2 studies in 9 results : IBA
  6. Tretinoin (Retinoic Acid) : 1 outcome 1 study in 18 results : FDA 27 Generic
  7. L 644711 (B-3(+)) : 1 outcome 1 study in 12 results : IBA
  8. Antigens : 1 outcome in 8 results : IBA
  9. Cystatin C : 1 outcome in 4 results : IBA
  10. Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase) : 1 outcome in 4 results : IBA
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Diseases Related to Spinal Dysraphism

  1. Anencephaly (Aprosencephaly)
  2. Neural Tube Defects (Exencephaly)
  3. Neurogenic Urinary Bladder (Bladder, Neurogenic)
  4. Chronic Kidney Failure (Chronic Renal Failure)
  5. Prostatic Neoplasms (Prostate Cancer)
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Key Therapies for Spinal Dysraphism

Efficacy Chart >>
  1. Transplants (Transplant) : 2 outcomes 1 study in 11 results
  2. Intermittent Urethral Catheterization : 1 outcome 2 studies in 25 results
  3. Urinary Diversion (Ileal Conduit) : 1 outcome 1 study in 9 results
  4. Solid-State Lasers : 1 outcome 1 study in 2 results
  5. Chemoprevention : 1 outcome 1 study in 2 results
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