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Didanosine (Videx) Summary

Description: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Also Known As: Videx; 2',3' Dideoxyinosine; Bristol-Myers Brand of Didanosine; Bristol-Myers Squibb Brand of Didanosine; NSC-612049 Show All >>

Networked: 549 relevant articles (24 outcomes, 111 trials/studies) for this Drug

Key Diseases for which Didanosine is Relevant

  1. HIV Infections (HIV Infection) : 8 outcomes 24 studies in 104 results
  2. Acquired Immunodeficiency Syndrome (AIDS) : 5 outcomes 52 studies in 156 results
  3. Infection : 3 outcomes 19 studies in 102 results
  4. Pancreatitis : 2 outcomes 5 studies in 65 results
  5. AIDS-Related Complex (ARC) : 1 outcome 12 studies in 26 results
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Drugs Related to Didanosine

  1. Zidovudine (Retrovir)
  2. Nevirapine (Viramune)
  3. Stavudine (Zerit)
  4. Zalcitabine (Hivid)
  5. Hydroxyurea (Hydrea)
  6. Immunoglobulins (Immunoglobulin)
  7. Lamivudine (3TC)
  8. efavirenz (Sustiva)
  9. emtricitabine (Emtriva)
  10. Biological Markers (Surrogate Marker)
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Therapies Related to Didanosine

  1. Art Therapy
  2. Aftercare (After-Treatment)
  3. Oral Administration
  4. Highly Active Antiretroviral Therapy (HAART)
  5. Drug Therapy (Chemotherapy)
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