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Integrins Summary

Description: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

Key Diseases for which Integrins is Relevant

  1. Neoplasms (Cancer) : 10 outcomes 82 studies in 989 results
  2. Glioma (Gliomas) : 4 outcomes 8 studies in 52 results
  3. Infection : 3 outcomes 14 studies in 181 results
  4. Multiple Sclerosis : 3 outcomes 1 study in 17 results
  5. Prostatic Neoplasms (Prostate Cancer) : 2 outcomes 15 studies in 64 results
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Drugs Related to Integrins

  1. Ligands
  2. arginyl-glycyl-aspartic acid
  3. Collagen
  4. Peptides
  5. Fibronectins (Fibronectin)
  6. Cilengitide
  7. Antigens
  8. Integrin alphaVbeta3
  9. EMD 121974
  10. Monoclonal Antibodies
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Therapies Related to Integrins

  1. Therapeutics
  2. Castration
  3. Immunotherapy
  4. Transplantation (Transplant Recipients)
  5. Heterologous Transplantation (Xenotransplantation)
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