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Scleritis (Episcleritis) Summary

Description: Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.

Also Known As: Episcleritis; Necrotizing Scleritis; Episcleritides; Necrotizing Scleritides; Scleritides Show All >>

Networked: 521 relevant articles (61 outcomes, 23 trials/studies) for this Disease

Key Drugs and Agents for Scleritis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. infliximab (Remicade) : 7 outcomes 2 studies in 25 results : FDA 2
  2. Steroids : 6 outcomes in 38 results : IBA
  3. rituximab (Mabthera) : 5 outcomes 2 studies in 19 results : FDA 3
  4. Adrenal Cortex Hormones (Corticosteroids) : 4 outcomes 1 study in 30 results : IBA
  5. Cyclosporine (Ciclosporin) : 3 outcomes 2 studies in 14 results : FDA 20 Generic
  6. Prednisolone (Predate) : 3 outcomes 2 studies in 12 results : FDA 55 Generic
  7. Cyclophosphamide (Cytoxan) : 2 outcomes in 15 results : FDA 10 Generic
  8. Anti-Bacterial Agents (Antibiotics) : 2 outcomes in 15 results : IBA
  9. Triamcinolone Acetonide (Azmacort) : 2 outcomes in 11 results : FDA 135 Generic
  10. Methylprednisolone : 2 outcomes in 5 results : FDA 18 Generic
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Diseases Related to Scleritis

  1. Inflammation
  2. Uveitis
  3. Rheumatoid Arthritis
  4. Scleritis (Episcleritis)
  5. Retinal Detachment (Retinal Detachments)
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Key Therapies for Scleritis

Efficacy Chart >>
  1. Injections : 4 outcomes in 11 results
  2. Aftercare (After-Treatment) : 4 outcomes in 6 results
  3. Transplants (Transplant) : 3 outcomes in 18 results
  4. Debridement : 1 outcome 1 study in 6 results
  5. Cryotherapy (Therapy, Cold) : 1 outcome in 5 results
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