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Histocompatibility Antigens Class I Summary

Description: Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.

Also Known As: Class I Histocompatibility Antigens; Class I Human Antigens; Class I Major Histocompatibility Antigens; Human Class I Antigens; Antigens, Class I Show All >>

Networked: 587 relevant articles (11 outcomes, 42 trials/studies) for this Bio-Agent

Key Diseases for which Histocompatibility Antigens Class I is Relevant

  1. Neoplasms (Cancer) : 6 outcomes 12 studies in 204 results
  2. Melanoma (Melanoma, Malignant) : 2 outcomes 9 studies in 64 results
  3. Neuroblastoma : 1 outcome 1 study in 8 results
  4. Colonic Neoplasms (Colon Cancer) : 1 outcome in 5 results
  5. B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) : 1 outcome in 3 results
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Drugs Related to Histocompatibility Antigens Class I

  1. Antigens
  2. Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
  3. DNA (Deoxyribonucleic Acid)
  4. HLA-A Antigens (HLA-A)
  5. Peptides
  6. Protein Sorting Signals (Signal Peptide)
  7. Antibodies
  8. Immunoglobulins (Immunoglobulin)
  9. I-antigen
  10. Cell Adhesion Molecules
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Therapies Related to Histocompatibility Antigens Class I

  1. Transplants (Transplant)
  2. Immunotherapy
  3. Homologous Transplantation (Allograft)
  4. Aftercare (After-Treatment)
  5. Heterologous Transplantation (Xenotransplantation)
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