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Leukotrienes Summary

Description: A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.

Key Diseases for which Leukotrienes is Relevant

  1. Asthma (Bronchial Asthma) : 29 outcomes 59 studies in 716 results
  2. Inflammation : 9 outcomes 14 studies in 459 results
  3. Urticaria (Hives) : 3 outcomes in 18 results
  4. Rhinitis : 2 outcomes 5 studies in 94 results
  5. Lung Injury : 2 outcomes 4 studies in 12 results
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Drugs Related to Leukotrienes

  1. Prostaglandins
  2. zileuton (Zyflo)
  3. montelukast (Singulair)
  4. Leukotriene Antagonists (Leukotriene Receptor Antagonists)
  5. Adrenal Cortex Hormones (Corticosteroids)
  6. Thromboxanes
  7. Immunoglobulin E (IgE)
  8. Arachidonic Acid (Vitamin F)
  9. Histamine (Histamine Dihydrochloride)
  10. Leukotriene C4
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Therapies Related to Leukotrienes

  1. Transplantation (Transplant Recipients)
  2. Immunotherapy
  3. Tourniquets
  4. Ligation
  5. Intravenous Infusions
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