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Zidovudine (Retrovir) Summary

Description: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Also Known As: Retrovir; Azidothymidine; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; AZT Antiviral; AZT, Antiviral; BW A509U; BWA-509U; 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; Antiviral AZT; BWA 509U; BWA509U; AZT (Antiviral); Thymidine, 3'-azido-3'-deoxy-

Networked: 2619 relevant articles (200 outcomes, 468 trials/studies) for this Drug

Key Diseases for which Zidovudine is Relevant

  1. Acquired Immunodeficiency Syndrome (AIDS) : 70 outcomes 229 studies in 941 results
  2. HIV Infections (HIV Infection) : 35 outcomes 83 studies in 491 results
  3. Infection : 32 outcomes 73 studies in 508 results
  4. AIDS-Related Complex (ARC) : 15 outcomes 42 studies in 124 results
  5. Thrombocytopenia (Thrombopenia) : 8 outcomes 3 studies in 54 results
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Drugs Related to Zidovudine

  1. Interferon-alpha (Interferon Alfa)
  2. Zidovudine (Retrovir)
  3. Didanosine (Videx)
  4. Lamivudine (3TC)
  5. Interferons
  6. Nevirapine (Viramune)
  7. Stavudine (Zerit)
  8. Electron Transport Complex IV (Cytochrome c Oxidase)
  9. I-antigen
  10. Zalcitabine (Hivid)
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Therapies Related to Zidovudine

  1. Drug Therapy (Chemotherapy)
  2. Highly Active Antiretroviral Therapy (HAART)
  3. Cesarean Section (Caesarean Section)
  4. Aftercare (After-Treatment)
  5. Art Therapy
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