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Tumor Necrosis Factor-alpha (Tumor Necrosis Factor) Summary

Description: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Also Known As: Tumor Necrosis Factor; TNF-alpha; Cachectin-Tumor Necrosis Factor; TNF Superfamily, Member 2; TNFalpha Show All >>

Networked: 46330 relevant articles (1959 outcomes, 5547 trials/studies) for this Bio-Agent

Key Diseases for which Tumor Necrosis Factor-alpha is Relevant

  1. Rheumatoid Arthritis : 187 outcomes 305 studies in 2469 results
  2. Neoplasms (Cancer) : 149 outcomes 434 studies in 4677 results
  3. Crohn Disease (Crohn's Disease) : 144 outcomes 82 studies in 923 results
  4. Necrosis : 137 outcomes 737 studies in 7767 results
  5. Inflammation : 124 outcomes 375 studies in 4678 results
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Drugs Related to Tumor Necrosis Factor-alpha

  1. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  2. infliximab (Remicade)
  3. Interleukin-6 (Interleukin 6)
  4. Cytokines
  5. TNFR-Fc fusion protein (etanercept)
  6. Antibodies
  7. adalimumab (Humira)
  8. Interleukin-10 (Interleukin 10)
  9. Messenger RNA (mRNA)
  10. Interleukins
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Therapies Related to Tumor Necrosis Factor-alpha

  1. Immunotherapy
  2. Drug Therapy (Chemotherapy)
  3. Biological Therapy
  4. Oral Administration
  5. Heterologous Transplantation (Xenotransplantation)
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