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Thrombasthenia (Glanzmann Thrombasthenia) Summary

Description: A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).

Also Known As: Glanzmann Thrombasthenia; Thrombasthenia of Glanzmann and Naegeli; Thrombasthenia, Glanzmann; Thrombasthenias

Networked: 631 relevant articles (14 outcomes, 43 trials/studies) for this Disease

Key Drugs and Agents for Thrombasthenia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. recombinant FVIIa (rFVIIa) : 6 outcomes 3 studies in 59 results : IBA
  2. Antibodies : 3 outcomes 2 studies in 36 results : IBA
  3. Factor VIIa (Activated Factor VII) : 3 outcomes 1 study in 23 results : IBA
  4. Glycoproteins (Glycoprotein) : 2 outcomes 5 studies in 163 results : IBA
  5. Platelet Glycoprotein GPIIb-IIIa Complex : 1 outcome 1 study in 39 results : IBA
  6. Thrombin : 1 outcome in 30 results : FDA 2
  7. Isoantibodies : 1 outcome in 11 results : IBA
  8. Tranexamic Acid (AMCA) : 1 outcome in 3 results : FDA 3
  9. Platelet Aggregation Inhibitors (Antiplatelet Drugs) : 1 outcome in 3 results : IBA
  10. Methotrexate (Mexate) : 1 outcome in 1 result : FDA 8 Generic
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Diseases Related to Thrombasthenia

  1. Hemorrhage
  2. Bernard-Soulier Syndrome (Giant Platelet Syndrome)
  3. Neonatal Alloimmune Thrombocytopenia
  4. Leukemia
  5. Acute Coronary Syndrome
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Key Therapies for Thrombasthenia

Efficacy Chart >>
  1. Platelet Transfusion (Blood Platelet Transfusions) : 5 outcomes 2 studies in 26 results
  2. Hematopoietic Stem Cell Transplantation : 1 outcome in 3 results
  3. Tonsillectomy : 1 outcome in 2 results
  4. Cardiopulmonary Bypass (Heart-Lung Bypass) : 1 outcome in 2 results
  5. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 1 study in 6 results
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