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Steroid 21-Hydroxylase (21 Hydroxylase) Summary

Description: An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Also Known As: 21 Hydroxylase; 21-Hydroxylase; Steroid 21 Monooxygenase; Cytochrome P-450 21-Hydroxylase; Cytochrome P-450 c21 Show All >>

Networked: 1330 relevant articles (11 outcomes, 81 trials/studies) for this Bio-Agent

Key Diseases for which Steroid 21-Hydroxylase is Relevant

  1. Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) : 6 outcomes 58 studies in 935 results
  2. Addison Disease (Addison's Disease) : 2 outcomes 3 studies in 66 results
  3. Virilism (Virilization) : 2 outcomes in 61 results
  4. Hypertension (High Blood Pressure) : 1 outcome in 4 results
  5. Cystic Fibrosis (Mucoviscidosis) : 1 outcome in 4 results
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Drugs Related to Steroid 21-Hydroxylase

  1. Autoantibodies
  2. Adrenocorticotropic Hormone (ACTH)
  3. Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
  4. Cortodoxone (11 Deoxycortisol)
  5. Biological Markers (Surrogate Marker)
  6. Trypsin
  7. Creatine Kinase (Creatine Phosphokinase)
  8. 17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)
  9. Aldosterone
  10. Renin
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Therapies Related to Steroid 21-Hydroxylase

  1. Adrenalectomy
  2. Aftercare (After-Treatment)
  3. Hysterectomy
  4. Drug Therapy (Chemotherapy)
  5. Arthroplasty
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