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Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase) Summary

Description: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Also Known As: 17 alpha Hydroxylase; CYP17; Hydroxyprogesterone Aldolase; Steroid 17 alpha-Monooxygenase; 17 alpha-Hydroxylase Cytochrome P-450 Show All >>

Networked: 592 relevant articles (12 outcomes, 119 trials/studies) for this Bio-Agent

Key Diseases for which Steroid 17-alpha-Hydroxylase is Relevant

  1. Prostatic Neoplasms (Prostate Cancer) : 11 outcomes 37 studies in 144 results
  2. Neoplasms (Cancer) : 1 outcome 10 studies in 78 results
  3. Prostatic Diseases : 1 outcome in 2 results
  4. Breast Neoplasms (Breast Cancer) : 25 studies in 78 results
  5. Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) : 5 studies in 25 results
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Drugs Related to Steroid 17-alpha-Hydroxylase

  1. Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
  2. abiraterone
  3. Androgen Receptors (Androgen Receptor)
  4. docetaxel (Taxotere)
  5. Cytochrome P-450 CYP1A1 (CYP1A1)
  6. Cytochromes
  7. Cytochrome P-450 Enzyme System (Cytochrome P450)
  8. Oxidoreductases
  9. DNA (Deoxyribonucleic Acid)
  10. Androgens
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Therapies Related to Steroid 17-alpha-Hydroxylase

  1. Castration
  2. Drug Therapy (Chemotherapy)
  3. Heterologous Transplantation (Xenotransplantation)
  4. Immunotherapy
  5. Chemoprevention
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