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Shy-Drager Syndrome Summary

Description: A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

Also Known As: Dysautonomia-Orthostatic Hypotension Syndrome; Syndrome, Dysautonomia-Orthostatic Hypotension; Autonomic Failures, Progressive; Dysautonomia Orthostatic Hypotension Syndrome; Dysautonomia-Orthostatic Hypotension Syndromes Show All >>

Networked: 142 relevant articles (3 outcomes, 6 trials/studies) for this Disease

Key Drugs and Agents for Shy-Drager Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Idiopathic orthostatic hypotension : 1 outcome 1 study in 21 results : IBA
  2. Propranolol (Inderal) : 1 outcome in 3 results : FDA 158 Generic
  3. Midodrine (Midon) : 1 outcome in 3 results : FDA 7 Generic
  4. Trimethaphan (Trimetaphan) : 1 outcome in 1 result : IBA
  5. Norepinephrine (Noradrenaline) : 1 study in 16 results : FDA 5 Generic
  6. Dopamine (Intropin) : 1 study in 5 results : FDA 36 Generic
  7. SAS : 1 study in 2 results : IBA
  8. Dopamine Agonists (Dopamine Agonist) : 1 study in 1 result : IBA
  9. Xenon : 1 study in 1 result : IBA
  10. GABA-A Receptors (GABA(A) Receptor) : 1 study in 1 result : IBA
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Diseases Related to Shy-Drager Syndrome

  1. Orthostatic Hypotension (Postural Hypotension)
  2. Multiple System Atrophy
  3. Parkinson Disease (Parkinson's Disease)
  4. Pure Autonomic Failure
  5. Hypertension (High Blood Pressure)
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Key Therapies for Shy-Drager Syndrome

Efficacy Chart >>
  1. Intravenous Infusions : 1 study in 3 results
  2. Denervation : 3 results
  3. General Anesthesia : 3 results
  4. Anesthesia : 3 results
  5. Sympathectomy (Sympathectomies) : 2 results
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