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Shwartzman Phenomenon (Shwartzman Reaction) Summary

Description: Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.

Also Known As: Shwartzman Reaction; Schwartzman Reaction; Phenomenon, Schwartzman; Phenomenon, Shwartzman; Schwartzman Reactions Show All >>

Networked: 349 relevant articles (11 outcomes, 20 trials/studies) for this Disease

Key Drugs and Agents for Shwartzman Phenomenon

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Fibrin : 2 outcomes 3 studies in 22 results : IBA
  2. Fibrinogen (Factor I) : 2 outcomes 1 study in 11 results : FDA 1
  3. Dacarbazine (DIC) : 1 outcome 4 studies in 13 results : FDA 10 Generic
  4. Complement System Proteins (Complement) : 1 outcome 1 study in 7 results : IBA
  5. Cytokines : 1 outcome 1 study in 3 results : IBA
  6. Heparin (Liquaemin) : 1 outcome in 16 results : FDA 74 Generic
  7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor) : 1 outcome in 12 results : IBA
  8. Mechlorethamine (Nitrogen Mustard) : 1 outcome in 10 results : FDA 1
  9. Cortisone : 1 outcome in 8 results : IBA
  10. Antibodies : 1 outcome in 6 results : IBA
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Diseases Related to Shwartzman Phenomenon

  1. Shock
  2. Sepsis (Septicemia)
  3. Necrosis
  4. Hepatitis
  5. Vasculitis (Vasculitides)
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Key Therapies for Shwartzman Phenomenon

Efficacy Chart >>
  1. Intravenous Injections : 1 study in 18 results
  2. Injections : 1 study in 17 results
  3. Intradermal Injections : 11 results
  4. Homologous Transplantation (Allograft) : 3 results
  5. Sympathectomy (Sympathectomies) : 2 results
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