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LDL Receptors (LDL Receptor) Summary

Description: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

Also Known As: LDL Receptor; Low Density Lipoprotein Receptor; Receptors, LDL; LDL Receptors, Lipoprotein; Low Density Lipoprotein Receptors Show All >>

Networked: 2588 relevant articles (76 outcomes, 286 trials/studies) for this Bio-Agent

Key Diseases for which LDL Receptors is Relevant

  1. Atherosclerosis : 28 outcomes 108 studies in 735 results
  2. Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) : 10 outcomes 52 studies in 833 results
  3. Hypercholesterolemia : 10 outcomes 30 studies in 331 results
  4. Hyperlipidemias (Hyperlipidemia) : 6 outcomes 14 studies in 78 results
  5. Coronary Disease (Coronary Heart Disease) : 4 outcomes 4 studies in 49 results
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Drugs Related to LDL Receptors

  1. Lipoproteins (Lipoprotein)
  2. Cholesterol
  3. Apolipoproteins
  4. Apolipoprotein A-I (Apolipoprotein A1)
  5. Apolipoproteins B (ApoB)
  6. Lipoprotein Lipase (Diacylglycerol Lipase)
  7. Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
  8. Subtilisin
  9. Chylomicron Remnants
  10. Apolipoproteins E (ApoE)
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Therapies Related to LDL Receptors

  1. Blood Component Removal (Apheresis)
  2. Transplantation (Transplant Recipients)
  3. Bone Marrow Transplantation (Transplantation, Bone Marrow)
  4. Lasers (Laser)
  5. Heterologous Transplantation (Xenotransplantation)
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