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Quadriplegia (Locked In Syndrome) Summary

Description: Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.

Also Known As: Locked In Syndrome; Spastic Quadriplegia; Tetraplegia; Quadriparesis; Flaccid Tetraplegia Show All >>

Networked: 1077 relevant articles (36 outcomes, 60 trials/studies) for this Disease

Key Drugs and Agents for Quadriplegia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Baclofen : 2 outcomes 2 studies in 22 results : FDA 31 Generic
  2. Anti-Bacterial Agents (Antibiotics) : 2 outcomes in 4 results : IBA
  3. NG-Nitroarginine Methyl Ester (L-NAME) : 1 outcome 2 studies in 5 results : IBA
  4. Potassium : 1 outcome 1 study in 17 results : IBA
  5. Glucose (Dextrose) : 1 outcome 1 study in 7 results : FDA 175 Generic
  6. Norepinephrine (Noradrenaline) : 1 outcome 1 study in 5 results : FDA 5 Generic
  7. levodopa drug combination carbidopa (Nakom) : 1 outcome 1 study in 3 results : FDA 3 Generic
  8. Niacin (Nicotinic Acid) : 1 outcome 1 study in 1 result : FDA 21 Generic
  9. Epinephrine (Adrenaline) : 1 outcome in 6 results : FDA 93 Generic
  10. Tissue Plasminogen Activator (Alteplase) : 1 outcome in 3 results : FDA 2
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Diseases Related to Quadriplegia

  1. Muscle Spasticity (Spastic)
  2. Respiratory Insufficiency (Respiratory Failure)
  3. Spinal Cord Injuries (Spinal Cord Injury)
  4. Hemiplegia (Spastic Hemiplegia)
  5. Wounds and Injuries (Trauma)
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Key Therapies for Quadriplegia

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 3 outcomes in 11 results
  2. Activities of Daily Living (ADL) : 2 outcomes in 19 results
  3. Drug Therapy (Chemotherapy) : 2 outcomes in 16 results
  4. Self-Help Devices (Assistive Technology) : 1 outcome 2 studies in 12 results
  5. Artificial Respiration (Mechanical Ventilation) : 1 outcome 1 study in 40 results
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