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Thrombotic Thrombocytopenic Purpura Summary

Description: An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.

Also Known As: Purpura, Thrombotic Thrombocytopenic; Congenital Thrombotic Thrombocytopenic Purpura; Familial Thrombotic Thrombocytopenic Purpura; Moschcowitz Disease; Schulman-Upshaw Syndrome Show All >>

Networked: 2396 relevant articles (126 outcomes, 74 trials/studies) for this Disease

Key Drugs and Agents for Thrombotic Thrombocytopenic Purpura

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. thymidine 5'-triphosphate (TTP) : 61 outcomes 37 studies in 1644 results : IBA
  2. rituximab (Mabthera) : 21 outcomes 5 studies in 115 results : FDA 3
  3. Vincristine (Oncovin) : 7 outcomes 1 study in 39 results : FDA 17 Generic
  4. von Willebrand Factor : 6 outcomes 14 studies in 237 results : IBA
  5. Adrenal Cortex Hormones (Corticosteroids) : 5 outcomes in 27 results : IBA
  6. Steroids : 3 outcomes 2 studies in 22 results : IBA
  7. Platelet Aggregation Inhibitors (Antiplatelet Drugs) : 3 outcomes 1 study in 22 results : IBA
  8. Immunoglobulin G (IgG) : 3 outcomes in 30 results : IBA
  9. Immunoglobulins (Immunoglobulin) : 3 outcomes in 20 results : IBA
  10. Aspirin (Acetylsalicylic Acid) : 3 outcomes in 12 results : FDA 80 Generic
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Diseases Related to Thrombotic Thrombocytopenic Purpura

  1. Hemolytic-Uremic Syndrome
  2. Thrombocytopenia (Thrombopenia)
  3. Thrombotic Microangiopathies
  4. Anemia
  5. Myasthenia Gravis
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Key Therapies for Thrombotic Thrombocytopenic Purpura

Efficacy Chart >>
  1. Plasma Exchange : 55 outcomes 17 studies in 317 results
  2. Plasmapheresis : 12 outcomes 2 studies in 91 results
  3. Splenectomy : 11 outcomes 1 study in 57 results
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 5 outcomes in 32 results
  5. Blood Component Removal (Apheresis) : 2 outcomes 4 studies in 15 results
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