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Progeria (Hutchinson Gilford Syndrome) Summary

Description: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.

Also Known As: Hutchinson Gilford Syndrome; Syndrome, Hutchinson-Gilford; Hutchinson-Gilford Syndrome

Networked: 261 relevant articles (6 outcomes, 16 trials/studies) for this Disease

Key Drugs and Agents for Progeria

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. prelamin A : 2 outcomes 2 studies in 30 results : IBA
  2. Lamin Type A (Lamin A) : 1 outcome 3 studies in 60 results : IBA
  3. Enzymes : 1 outcome 2 studies in 8 results : IBA
  4. Farnesyltranstransferase (Farnesyltransferase) : 1 outcome in 6 results : IBA
  5. Adenosine Triphosphate (ATP) : 1 outcome in 3 results : IBA
  6. p21(ras) farnesyl-protein transferase (protein farnesyltransferase) : 1 outcome in 2 results : IBA
  7. Staphylococcal Protein A (A, Protein) : 1 outcome in 1 result : IBA
  8. Lovastatin (Mevacor) : 1 outcome in 1 result : FDA 14 Generic
  9. Reactive Oxygen Species (Oxygen Radicals) : 2 studies in 2 results : IBA
  10. Hutchinson Gilford progeria syndrome : 1 study in 23 results : IBA
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Diseases Related to Progeria

  1. Werner Syndrome (Werner's Syndrome)
  2. Premature Aging
  3. Down Syndrome (Down's Syndrome)
  4. Neoplasms (Cancer)
  5. Cockayne Syndrome (Syndrome, Cockayne)
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Key Therapies for Progeria

Efficacy Chart >>
  1. Transplants (Transplant) : 1 result
  2. Prostheses and Implants (Prosthesis) : 1 result
  3. Transplantation (Transplant Recipients) : 1 result
  4. Therapeutics : 1 result
  5. Oral Surgery (Maxillofacial Surgery) : 1 result
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