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Pheochromocytoma Summary

Description: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Also Known As: Extra-Adrenal Pheochromocytoma; Extra-Adrenal Pheochromocytomas; Pheochromocytoma, Extra Adrenal; Pheochromocytomas; Pheochromocytomas, Extra-Adrenal Show All >>

Networked: 6748 relevant articles (170 outcomes, 660 trials/studies) for this Disease

Key Drugs and Agents for Pheochromocytoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. 3-Iodobenzylguanidine (Iobenguane) : 26 outcomes 24 studies in 311 results : IBA
  2. Hydrogen Peroxide (Hydroperoxide) : 9 outcomes 19 studies in 63 results : FDA 1 Generic
  3. Catecholamines : 5 outcomes 31 studies in 545 results : IBA
  4. Norepinephrine (Noradrenaline) : 5 outcomes 25 studies in 321 results : FDA 5 Generic
  5. Metanephrine : 5 outcomes 7 studies in 117 results : IBA
  6. Aldosterone : 4 outcomes 7 studies in 98 results : IBA
  7. Normetanephrine : 4 outcomes 4 studies in 76 results : IBA
  8. Dopamine (Intropin) : 3 outcomes 15 studies in 197 results : FDA 36 Generic
  9. Adrenergic Receptors (Adrenergic Receptor) : 3 outcomes 6 studies in 35 results : IBA
  10. Phenoxybenzamine : 3 outcomes 4 studies in 53 results : FDA 1
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Diseases Related to Pheochromocytoma

  1. Neoplasms (Cancer)
  2. Paraganglioma (Paragangliomas)
  3. Cushing Syndrome
  4. Hypertension (High Blood Pressure)
  5. Neuroblastoma
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Key Therapies for Pheochromocytoma

Efficacy Chart >>
  1. Adrenalectomy : 34 outcomes 38 studies in 513 results
  2. Drug Therapy (Chemotherapy) : 3 outcomes 6 studies in 50 results
  3. Anesthesia : 2 outcomes 3 studies in 130 results
  4. Combination Drug Therapy (Combination Chemotherapy) : 2 outcomes 1 study in 16 results
  5. Ligation : 1 outcome 3 studies in 15 results
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