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Phenytoin (Dilantin) Summary

Description: An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.

Also Known As: Dilantin; Epanutin; Diphenylhydantoin; 5,5-Diphenylhydantoin; Antisacer Show All >>

Networked: 4616 relevant articles (332 outcomes, 530 trials/studies) for this Drug

Key Diseases for which Phenytoin is Relevant

  1. Seizures (Seizure) : 145 outcomes 174 studies in 1421 results
  2. Epilepsy (Aura) : 29 outcomes 75 studies in 677 results
  3. Status Epilepticus (Complex Partial Status Epilepticus) : 22 outcomes 14 studies in 202 results
  4. Partial Epilepsies (Epilepsy, Partial) : 11 outcomes 9 studies in 52 results
  5. Pain (Aches) : 11 outcomes 5 studies in 59 results
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Drugs Related to Phenytoin

  1. Carbamazepine (Tegretol)
  2. Phenobarbital (Luminal)
  3. Valproic Acid (Valproate, Semisodium)
  4. Anticonvulsants (Antiepileptic Drugs)
  5. Diazepam (Valium)
  6. Sodium
  7. lamotrigine (Lamictal)
  8. etiracetam (levetiracetam)
  9. topiramate (Topamax)
  10. oxcarbazepine (Trileptal)
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Therapies Related to Phenytoin

  1. Vagus Nerve Stimulation
  2. Relaxation Therapy
  3. Psychology Biofeedback (Biofeedback)
  4. Craniotomy
  5. Oral Administration
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