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Ornithine Decarboxylase (Decarboxylase, Ornithine) Summary

Description: A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine. EC 4.1.1.17.

Also Known As: Decarboxylase, Ornithine; Carboxy-lyase, Ornithine; Ornithine Carboxy lyase; Ornithine Carboxy-lyase; L-Ornithine carboxy-lyase

Networked: 1520 relevant articles (24 outcomes, 129 trials/studies) for this Bio-Agent

Key Diseases for which Ornithine Decarboxylase is Relevant

  1. Neoplasms (Cancer) : 5 outcomes 41 studies in 553 results
  2. Skin Neoplasms (Skin Cancer) : 3 outcomes in 8 results
  3. Starvation : 2 outcomes in 21 results
  4. Hyperplasia : 1 outcome 11 studies in 62 results
  5. Colonic Neoplasms (Colon Cancer) : 1 outcome 4 studies in 28 results
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Drugs Related to Ornithine Decarboxylase

  1. Eflornithine (Ornidyl)
  2. Putrescine
  3. Spermidine
  4. Adenosylmethionine Decarboxylase
  5. DNA (Deoxyribonucleic Acid)
  6. anthracene
  7. 9,10-Dimethyl-1,2-benzanthracene (DMBA)
  8. Dinoprostone (PGE2)
  9. Testosterone (Sustanon)
  10. ornithine decarboxylase antizyme
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Therapies Related to Ornithine Decarboxylase

  1. Chemoprevention
  2. Oral Administration
  3. Drug Therapy (Chemotherapy)
  4. Ovariectomy (Oophorectomy)
  5. Hepatectomy
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