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Nitric Oxide (Nitrogen Monoxide) Summary

Description: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Also Known As: Nitrogen Monoxide; Endogenous Nitrate Vasodilator; Mononitrogen Monoxide; Nitric Oxide, Endothelium-Derived; Endothelium-Derived Nitric Oxide Show All >>

Networked: 25417 relevant articles (814 outcomes, 3103 trials/studies) for this Drug

Key Diseases for which Nitric Oxide is Relevant

  1. Pulmonary Hypertension (Ayerza Syndrome) : 84 outcomes 113 studies in 1035 results
  2. Reperfusion Injury : 46 outcomes 55 studies in 534 results
  3. Asthma (Bronchial Asthma) : 43 outcomes 177 studies in 1320 results
  4. Inflammation : 42 outcomes 202 studies in 2500 results
  5. Infection : 39 outcomes 66 studies in 929 results
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Drugs Related to Nitric Oxide

  1. Nitric Oxide Synthase (NO Synthase)
  2. Arginine (L-Arginine)
  3. Cytokines
  4. Oxygen
  5. Epoprostenol (Prostacyclin)
  6. NG-Nitroarginine Methyl Ester (L-NAME)
  7. Glutathione (Reduced Glutathione)
  8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  9. Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
  10. Nitroglycerin (Dynamite)
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Therapies Related to Nitric Oxide

  1. Extracorporeal Membrane Oxygenation (ECMO)
  2. Transplants (Transplant)
  3. Oral Administration
  4. Lasers (Laser)
  5. Aftercare (After-Treatment)
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