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Neurosyphilis
(General Paresis of the Insane)
Summary
Description:
Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
Also Known As:
General Paresis of the Insane; Central Nervous System Syphilis; General Paralysis; Neurosyphilis, Asymptomatic; Neurosyphilis, Gummatous Show All >>
Networked: 602
relevant articles (28 outcomes,
37 trials/studies)
for this Disease
Key Drugs and Agents for Neurosyphilis
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
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Penicillins (Penicillin)
:
11 outcomes 12 studies in 233 results
:
FDA 1
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Antibodies
:
2 outcomes 3 studies in 41 results
: IBA
-
Penicillin G (Benzylpenicillin)
:
2 outcomes 1 study in 36 results
:
FDA 31
Generic
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Azithromycin (Zithromax)
:
2 outcomes in 5 results
:
FDA 39
Generic
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Immunoglobulin M (IgM)
:
1 outcome 1 study in 27 results
: IBA
-
Penicillin G Benzathine (LPG)
:
1 outcome 1 study in 21 results
:
FDA 6
-
Ceftriaxone (Ceftriaxon)
:
1 outcome 1 study in 12 results
:
FDA 33
Generic
-
Immunoglobulins (Immunoglobulin)
:
1 outcome 1 study in 9 results
: IBA
-
Penicillin G Procaine (Procaine, Benzylpenicillin)
:
1 outcome 1 study in 8 results
:
FDA 7
-
Doxycycline (Vibramycin)
:
1 outcome 1 study in 6 results
:
FDA 23
Generic
Show All >>
Diseases Related to Neurosyphilis
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Syphilis
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Infection
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Neurosyphilis (General Paresis of the Insane)
-
Urethritis
-
Lymphogranuloma Venereum
Show All >>
Key Therapies for Neurosyphilis
Efficacy Chart >>
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Aftercare (After-Treatment)
:
3 outcomes 1 study in 24 results
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Induced Hyperthermia (Thermotherapy)
:
1 study in 15 results
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Drug Therapy (Chemotherapy)
:
1 study in 5 results
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Highly Active Antiretroviral Therapy (HAART)
:
3 results
-
Transplants (Transplant)
:
2 results
Show All >>
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