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Neurosyphilis (General Paresis of the Insane) Summary

Description: Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)

Also Known As: General Paresis of the Insane; Central Nervous System Syphilis; General Paralysis; Neurosyphilis, Asymptomatic; Neurosyphilis, Gummatous Show All >>

Networked: 602 relevant articles (28 outcomes, 37 trials/studies) for this Disease

Key Drugs and Agents for Neurosyphilis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Penicillins (Penicillin) : 11 outcomes 12 studies in 233 results : FDA 1
  2. Antibodies : 2 outcomes 3 studies in 41 results : IBA
  3. Penicillin G (Benzylpenicillin) : 2 outcomes 1 study in 36 results : FDA 31 Generic
  4. Azithromycin (Zithromax) : 2 outcomes in 5 results : FDA 39 Generic
  5. Immunoglobulin M (IgM) : 1 outcome 1 study in 27 results : IBA
  6. Penicillin G Benzathine (LPG) : 1 outcome 1 study in 21 results : FDA 6
  7. Ceftriaxone (Ceftriaxon) : 1 outcome 1 study in 12 results : FDA 33 Generic
  8. Immunoglobulins (Immunoglobulin) : 1 outcome 1 study in 9 results : IBA
  9. Penicillin G Procaine (Procaine, Benzylpenicillin) : 1 outcome 1 study in 8 results : FDA 7
  10. Doxycycline (Vibramycin) : 1 outcome 1 study in 6 results : FDA 23 Generic
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Diseases Related to Neurosyphilis

  1. Syphilis
  2. Infection
  3. Neurosyphilis (General Paresis of the Insane)
  4. Urethritis
  5. Lymphogranuloma Venereum
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Key Therapies for Neurosyphilis

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 3 outcomes 1 study in 24 results
  2. Induced Hyperthermia (Thermotherapy) : 1 study in 15 results
  3. Drug Therapy (Chemotherapy) : 1 study in 5 results
  4. Highly Active Antiretroviral Therapy (HAART) : 3 results
  5. Transplants (Transplant) : 2 results
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