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Necrosis Summary

Description: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. Distinguish it from APOPTOSIS which is a normal, regulated cellular process.

Also Known As: Necroses

Networked: 55292 relevant articles (1636 outcomes, 3680 trials/studies) for this Disease

Key Drugs and Agents for Necrosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor) : 137 outcomes 737 studies in 7767 results : IBA
  2. infliximab (Remicade) : 75 outcomes 47 studies in 465 results : FDA 2
  3. Interleukins : 32 outcomes 204 studies in 2480 results : IBA
  4. Creatinine : 29 outcomes 7 studies in 417 results : IBA
  5. adalimumab (Humira) : 27 outcomes 21 studies in 176 results : FDA 2
  6. Cytokines : 26 outcomes 238 studies in 2816 results : IBA
  7. Interleukin-6 (Interleukin 6) : 25 outcomes 268 studies in 3243 results : IBA
  8. Acetaminophen (Paracetamol) : 25 outcomes 36 studies in 572 results : FDA 409 Generic
  9. TNFR-Fc fusion protein (etanercept) : 25 outcomes 31 studies in 230 results : FDA 2
  10. Methotrexate (Mexate) : 21 outcomes 27 studies in 206 results : FDA 8 Generic
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Diseases Related to Necrosis

  1. Neoplasms (Cancer)
  2. Inflammation
  3. Rheumatoid Arthritis
  4. Ischemia
  5. Crohn Disease (Crohn's Disease)
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Key Therapies for Necrosis

Efficacy Chart >>
  1. Transplants (Transplant) : 52 outcomes 90 studies in 1862 results
  2. Drug Therapy (Chemotherapy) : 36 outcomes 35 studies in 795 results
  3. Debridement : 26 outcomes 10 studies in 384 results
  4. Lasers (Laser) : 16 outcomes 29 studies in 429 results
  5. Aftercare (After-Treatment) : 15 outcomes 19 studies in 482 results
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