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Lovastatin (Mevacor) Summary

Description: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.

Also Known As: Mevacor; 6-Methylcompactin; Lovastatin, (1 alpha(S*))-Isomer; Lovastatin, 1 alpha-Isomer (without R*/S* notation); MK-803; Monacolin K; 6 Methylcompactin; MK 803; MK803; Mevinolin; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-

Networked: 1199 relevant articles (122 outcomes, 262 trials/studies) for this Drug

Key Diseases for which Lovastatin is Relevant

  1. Hypercholesterolemia : 24 outcomes 46 studies in 221 results
  2. Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) : 10 outcomes 8 studies in 56 results
  3. Nephrotic Syndrome (Syndrome, Nephrotic) : 8 outcomes 4 studies in 19 results
  4. Neoplasms (Cancer) : 7 outcomes 17 studies in 140 results
  5. Hyperlipidemias (Hyperlipidemia) : 7 outcomes 11 studies in 59 results
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Drugs Related to Lovastatin

  1. Cholesterol
  2. Simvastatin (Zocor)
  3. LDL Cholesterol
  4. Pravastatin (Pravachol)
  5. Lipoproteins (Lipoprotein)
  6. Colestipol (Colestid)
  7. Gemfibrozil (Lopid)
  8. Niacin (Nicotinic Acid)
  9. atorvastatin (Lipitor)
  10. fluvastatin
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Therapies Related to Lovastatin

  1. Heart Transplantation (Grafting, Heart)
  2. Diet Therapy (Therapy, Diet)
  3. Combination Drug Therapy (Combination Chemotherapy)
  4. Continuous Ambulatory Peritoneal Dialysis (CAPD)
  5. Cardiopulmonary Resuscitation (CPR)
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