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Lecithin Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency) Summary

Description: An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.

Also Known As: Lecithin:Cholesterol Acyltransferase Deficiency; Fish-Eye Disease; Deficiency, Lecithin Acyltransferase; Dyslipoproteinemic Corneal Dystrophy; LCAT Deficiency Show All >>

Networked: 310 relevant articles (10 outcomes, 31 trials/studies) for this Disease

Key Drugs and Agents for Lecithin Acyltransferase Deficiency

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Apolipoprotein A-I (Apolipoprotein A1) : 4 outcomes 4 studies in 38 results : IBA
  2. Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase) : 3 outcomes 10 studies in 152 results : IBA
  3. Lipoproteins (Lipoprotein) : 2 outcomes 13 studies in 96 results : IBA
  4. Cholesterol : 2 outcomes 3 studies in 66 results : IBA
  5. HDL Cholesterol : 2 outcomes in 23 results : IBA
  6. HDL Lipoproteins : 1 outcome 5 studies in 22 results : IBA
  7. Apolipoproteins E (ApoE) : 1 outcome 1 study in 10 results : IBA
  8. Triglycerides (Triacylglycerol) : 1 outcome 1 study in 5 results : IBA
  9. Sterol O-Acyltransferase : 1 outcome in 5 results : IBA
  10. very low density lipoprotein triglyceride : 1 outcome in 2 results : IBA
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Diseases Related to Lecithin Acyltransferase Deficiency

  1. Lecithin Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)
  2. Corneal Opacity
  3. Tangier Disease
  4. Arteriosclerosis
  5. Atherosclerosis
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Key Therapies for Lecithin Acyltransferase Deficiency

Efficacy Chart >>
  1. Fat-Restricted Diet (Diet, Fat Restricted) : 1 study in 2 results
  2. Hormone Replacement Therapy (Therapy, Hormone Replacement) : 1 study in 1 result
  3. Kidney Transplantation : 5 results
  4. Total Parenteral Nutrition : 2 results
  5. Enzyme Replacement Therapy : 1 result
Show All >>

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