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Job's Syndrome (Hyper-IgE Syndrome) Summary

Description: Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.

Also Known As: Hyper-IgE Syndrome; Job Syndrome; Syndrome, Hyper-IgE; HIES, Autosomal Dominant; Hyper-IgE Syndrome, Autosomal Dominant Show All >>

Networked: 295 relevant articles (11 outcomes, 17 trials/studies) for this Disease

Key Drugs and Agents for Job's Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Immunoglobulin E (IgE) : 3 outcomes 8 studies in 182 results : IBA
  2. Anti-Bacterial Agents (Antibiotics) : 2 outcomes in 3 results : IBA
  3. Cyclosporine (Ciclosporin) : 2 outcomes in 2 results : FDA 20 Generic
  4. Intravenous Immunoglobulins (IVIG) : 1 outcome 1 study in 3 results : FDA 1
  5. anti-IgE : 1 outcome in 2 results : IBA
  6. Fluoroquinolones : 1 outcome in 1 result : IBA
  7. Fluconazole (Zonal) : 1 outcome in 1 result : FDA 41 Generic
  8. Exotoxins : 1 outcome in 1 result : IBA
  9. Neocate : 1 outcome in 1 result : IBA
  10. Staphylococcal enterotoxin A : 1 outcome in 1 result : IBA
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Diseases Related to Job's Syndrome

  1. Infection
  2. Pneumonia (Pneumonitis)
  3. Atopic Dermatitis (Atopic Eczema)
  4. Abscess
  5. Hypergammaglobulinemia (Hyperimmunoglobulinemia)
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Key Therapies for Job's Syndrome

Efficacy Chart >>
  1. Plasmapheresis : 2 outcomes in 2 results
  2. Drug Therapy (Chemotherapy) : 1 outcome in 2 results
  3. Transplants (Transplant) : 4 results
  4. Hematopoietic Stem Cell Transplantation : 2 results
  5. Cell Transplantation : 2 results
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