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Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase) Summary

Description: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.

Also Known As: Hypoxanthine Guanine Phosphoribosyltransferase; HPRT; HGPRT; HPRTase; Phosphoribosyltransferase, Guanine Show All >>

Networked: 1013 relevant articles (4 outcomes, 75 trials/studies) for this Bio-Agent

Key Diseases for which Hypoxanthine Phosphoribosyltransferase is Relevant

  1. Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) : 2 outcomes 9 studies in 307 results
  2. Neoplasms (Cancer) : 1 outcome 11 studies in 101 results
  3. Nervous System Diseases (Neurological Disorders) : 1 outcome 1 study in 13 results
  4. Inborn Errors Metabolism (Inborn Errors of Metabolism) : 1 outcome in 1 result
  5. Chromosome Aberrations (Chromosome Abnormalities) : 12 studies in 102 results
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Drugs Related to Hypoxanthine Phosphoribosyltransferase

  1. Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
  2. Fluorouracil (Carac)
  3. Hypoxanthine
  4. Transferases
  5. Guanine
  6. DNA (Deoxyribonucleic Acid)
  7. tributyl phosphate (TBP)
  8. Thioguanine (Tioguanine)
  9. Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
  10. purine
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Therapies Related to Hypoxanthine Phosphoribosyltransferase

  1. Drug Therapy (Chemotherapy)
  2. Radiotherapy
  3. Aftercare (After-Treatment)
  4. Heterologous Transplantation (Xenotransplantation)
  5. Caloric Restriction
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