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Disorders of Excessive Somnolence (Hypersomnia) Summary

Description: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)

Also Known As: Hypersomnia; Hypersomnolence; DOES (Disorders of Excessive Somnolence); Excessive Somnolence Disorders; Hypersomnia, Recurrent Show All >>

Networked: 361 relevant articles (35 outcomes, 25 trials/studies) for this Disease

Key Drugs and Agents for Disorders of Excessive Somnolence

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. modafinil (armodafinil) : 7 outcomes 3 studies in 32 results : FDA 10
  2. orexins (orexin) : 4 outcomes 5 studies in 52 results : IBA
  3. Sodium Oxybate (gamma Hydroxybutyrate) : 2 outcomes 2 studies in 6 results : FDA 1
  4. Antidepressive Agents (Antidepressants) : 2 outcomes in 7 results : IBA
  5. Thyroxine (Levothyroxine) : 2 outcomes in 2 results : FDA 13 Generic
  6. Clarithromycin (Biaxin) : 1 outcome 1 study in 2 results : FDA 22 Generic
  7. Oxygen : 1 outcome in 11 results : IBA
  8. Methylphenidate (Ritalin) : 1 outcome in 9 results : FDA 25 Generic
  9. Amphetamine (Amfetamine) : 1 outcome in 7 results : FDA 15 Generic
  10. Dopamine (Intropin) : 1 outcome in 5 results : FDA 36 Generic
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Diseases Related to Disorders of Excessive Somnolence

  1. Narcolepsy
  2. Disorders of Excessive Somnolence (Hypersomnia)
  3. Cataplexy
  4. Hyperphagia
  5. Snoring
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Key Therapies for Disorders of Excessive Somnolence

Efficacy Chart >>
  1. Tracheostomy : 3 outcomes 1 study in 12 results
  2. Aftercare (After-Treatment) : 3 outcomes in 4 results
  3. Continuous Positive Airway Pressure : 1 outcome in 5 results
  4. Tonsillectomy : 1 outcome in 2 results
  5. Bariatric Surgery : 1 study in 1 result
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