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Gonadal Dysgenesis (Gonadal Agenesis) Summary

Description: A number of syndromes with defective gonadal developments such as streak GONADS and dysgenetic testes or ovaries. The spectrum of gonadal and sexual abnormalities is reflected in their varied sex chromosome (SEX CHROMOSOMES) constitution as shown by the karyotypes of 45,X monosomy (TURNER SYNDROME); 46,XX (GONADAL DYSGENESIS, 46XX); 46,XY (GONADAL DYSGENESIS, 46,XY); and sex chromosome MOSAICISM; (GONADAL DYSGENESIS, MIXED). Their phenotypes range from female, through ambiguous, to male. This concept includes gonadal agenesis.

Also Known As: Gonadal Agenesis; Dysgenesis, Gonadal

Networked: 419 relevant articles (2 outcomes, 35 trials/studies) for this Disease

Key Drugs and Agents for Gonadal Dysgenesis

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Drugs and Important Biological Agents (IBA) related to treatments:
  1. H-Y Antigen : 1 outcome 2 studies in 19 results : IBA
  2. Estrogens (Estrogen) : 3 studies in 41 results : FDA 1
  3. DNA (Deoxyribonucleic Acid) : 3 studies in 21 results : IBA
  4. Androgen Receptors (Androgen Receptor) : 3 studies in 5 results : IBA
  5. Gonadotropins : 2 studies in 31 results : IBA
  6. Hormones : 2 studies in 22 results : IBA
  7. Testosterone (Sustanon) : 2 studies in 17 results : FDA 13
  8. Prostaglandins D (PGD) : 2 studies in 14 results : IBA
  9. Follicle Stimulating Hormone (Follitropin) : 2 studies in 8 results : FDA 1
  10. XY female 46 : 1 study in 26 results : IBA
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Diseases Related to Gonadal Dysgenesis

  1. Androgen-Insensitivity Syndrome (Testicular Feminization)
  2. Turner Syndrome (Turner's Syndrome)
  3. Ovotesticular Disorders of Sex Development
  4. Disorders of Sex Development (Intersexuality)
  5. Gonadal Dysgenesis (Gonadal Agenesis)
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Key Therapies for Gonadal Dysgenesis

Efficacy Chart >>
  1. Laparotomy : 1 outcome in 3 results
  2. Estrogen Replacement Therapy : 2 studies in 5 results
  3. Hormone Replacement Therapy (Therapy, Hormone Replacement) : 5 results
  4. Ovariectomy (Oophorectomy) : 5 results
  5. Drug Therapy (Chemotherapy) : 4 results
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