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Fibrinogen
(Factor I)
Summary
Description:
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Also Known As:
Factor I; Blood Coagulation Factor I; gamma-Fibrinogen; Factor I, Coagulation; I, Coagulation Factor Show All >>
Networked: 10189
relevant articles (263 outcomes,
1183 trials/studies)
for this Drug
Key Diseases for which Fibrinogen is
Relevant
-
Hemorrhage
:
37 outcomes 67 studies in 717 results
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Neoplasms (Cancer)
:
16 outcomes 50 studies in 475 results
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Thrombosis (Thrombus)
:
15 outcomes 39 studies in 803 results
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Wounds and Injuries (Trauma)
:
14 outcomes 26 studies in 265 results
-
Stroke (Strokes)
:
9 outcomes 98 studies in 421 results
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Drugs Related to Fibrinogen
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C-Reactive Protein
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Fibrin
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Thrombin
-
Heparin (Liquaemin)
-
fibrin fragment D (D-dimer)
-
Plasminogen Activators (Plasminogen Activator)
-
LDL Cholesterol
-
Antithrombin III
-
Cholesterol
-
Insulin (Novolin)
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Therapies Related to Fibrinogen
-
Blood Component Removal (Apheresis)
-
Transplants (Transplant)
-
Plasmapheresis
-
Spinal Fusion (Spondylosyndesis)
-
Lasers (Laser)
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