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Fanconi Anemia (Fanconi's Anemia) Summary

Description: Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)

Also Known As: Fanconi's Anemia; Anemia, Fanconi's; Anemias, Fanconi; Fanconi Anemias; Anemia, Fanconi

Networked: 1214 relevant articles (20 outcomes, 62 trials/studies) for this Disease

Key Drugs and Agents for Fanconi Anemia

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Drugs and Important Biological Agents (IBA) related to treatments:
  1. DNA (Deoxyribonucleic Acid) : 2 outcomes 12 studies in 369 results : IBA
  2. Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) : 2 outcomes 2 studies in 6 results : IBA
  3. Alkylating Agents : 2 outcomes in 17 results : IBA
  4. erythritol anhydride (butanedione) : 1 outcome 4 studies in 35 results : IBA
  5. Fanconi Anemia Complementation Group D2 Protein : 1 outcome 2 studies in 15 results : IBA
  6. Transferases : 1 outcome 1 study in 4 results : IBA
  7. Bone Marrow failure syndromes : 1 outcome in 22 results : IBA
  8. Reactive Oxygen Species (Oxygen Radicals) : 1 outcome in 11 results : IBA
  9. Proliferating Cell Nuclear Antigen (PCNA) : 1 outcome in 6 results : IBA
  10. Hormones : 1 outcome in 4 results : IBA
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Diseases Related to Fanconi Anemia

  1. Leukemia
  2. Pancytopenia
  3. Hypersensitivity (Allergy)
  4. Chromosome Breakage
  5. Hepatocellular Carcinoma (Hepatoma)
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Key Therapies for Fanconi Anemia

Efficacy Chart >>
  1. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 3 outcomes 2 studies in 57 results
  2. Transplants (Transplant) : 2 outcomes 4 studies in 39 results
  3. Transplantation (Transplant Recipients) : 1 outcome 3 studies in 36 results
  4. Hematopoietic Stem Cell Transplantation : 1 outcome 2 studies in 28 results
  5. Cell Transplantation : 1 outcome in 15 results
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