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Etoposide (VP 16) Summary

Description: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Also Known As: VP 16; Eposide; Lastet; Toposar; Vepesid Show All >>

Networked: 8030 relevant articles (812 outcomes, 1889 trials/studies) for this Drug

Key Diseases for which Etoposide is Relevant

  1. Neoplasms (Cancer) : 131 outcomes 310 studies in 1797 results
  2. Small Cell Lung Carcinoma (Small Cell Lung Cancer) : 84 outcomes 321 studies in 795 results
  3. Lymphoma (Lymphomas) : 61 outcomes 91 studies in 448 results
  4. Acute Myeloid Leukemia (Acute Myelogenous Leukemia) : 47 outcomes 74 studies in 310 results
  5. Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) : 45 outcomes 68 studies in 289 results
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Drugs Related to Etoposide

  1. Cisplatin (Platino)
  2. Cyclophosphamide (Cytoxan)
  3. Carboplatin (JM8)
  4. Doxorubicin (Adriamycin)
  5. Ifosfamide
  6. Vincristine (Oncovin)
  7. Cytarabine (Cytosar-U)
  8. Bleomycin (Blenoxane)
  9. Etoposide (VP 16)
  10. Prednisone (Sone)
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Therapies Related to Etoposide

  1. Drug Therapy (Chemotherapy)
  2. Combination Drug Therapy (Combination Chemotherapy)
  3. Radiotherapy
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
  5. Salvage Therapy
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