Search Login Register

Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic) Summary

Description: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Also Known As: Epilepsy, Tonic Clonic; Major Epilepsy; Epilepsy, Tonic-Clonic; Convulsions, Grand Mal; Cryptogenic Tonic-Clonic Epilepsy Show All >>

Networked: 233 relevant articles (12 outcomes, 12 trials/studies) for this Disease

Key Drugs and Agents for Tonic-Clonic Epilepsy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Diazepam (Valium) : 3 outcomes 1 study in 10 results : FDA 84 Generic
  2. Paraldehyde : 2 outcomes 2 studies in 3 results : IBA
  3. Anticonvulsants (Antiepileptic Drugs) : 2 outcomes 1 study in 11 results : IBA
  4. Pentylenetetrazole (Metrazol) : 2 outcomes in 12 results : IBA
  5. Picrotoxin : 2 outcomes in 7 results : IBA
  6. Phenobarbital (Luminal) : 1 outcome 1 study in 10 results : FDA 1
  7. Lorazepam (Ativan) : 1 outcome 1 study in 4 results : FDA 71 Generic
  8. Midazolam (Versed) : 1 outcome 1 study in 2 results : FDA 31 Generic
  9. topiramate (Topamax) : 1 outcome 1 study in 2 results : FDA 28 Generic
  10. Valproic Acid (Valproate, Semisodium) : 1 outcome in 11 results : FDA 51 Generic
Show All >>

Diseases Related to Tonic-Clonic Epilepsy

  1. Seizures (Seizure)
  2. Myoclonus (Nocturnal Myoclonus)
  3. Epilepsy (Aura)
  4. Febrile Seizures (Febrile Seizure)
  5. Partial Epilepsies (Epilepsy, Partial)
Show All >>

Key Therapies for Tonic-Clonic Epilepsy

Efficacy Chart >>
  1. Hemispherectomy : 1 study in 1 result
  2. Therapeutics : 1 study in 1 result
  3. Anesthesia : 4 results
  4. Subcutaneous Injections : 2 results
  5. Injections : 2 results
Show All >>

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.