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Toxic Epidermal Necrolysis (Lyell's Syndrome) Summary

Description: An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure.

Also Known As: Lyell's Syndrome; Epidermal Necrolysis, Toxic; Nonstaphylococcal Scalded Skin Syndrome; Epidermal Necrolyses, Toxic; Lyell Syndrome Show All >>

Networked: 1143 relevant articles (34 outcomes, 54 trials/studies) for this Disease

Key Drugs and Agents for Toxic Epidermal Necrolysis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Immunoglobulins (Immunoglobulin) : 11 outcomes 6 studies in 81 results : IBA
  2. Intravenous Immunoglobulins (IVIG) : 6 outcomes 4 studies in 43 results : FDA 1
  3. Adrenal Cortex Hormones (Corticosteroids) : 2 outcomes in 22 results : IBA
  4. Antibodies : 2 outcomes in 6 results : IBA
  5. Cyclophosphamide (Cytoxan) : 2 outcomes in 4 results : FDA 10 Generic
  6. Anticonvulsants (Antiepileptic Drugs) : 1 outcome 4 studies in 41 results : IBA
  7. Phenytoin (Dilantin) : 1 outcome 3 studies in 44 results : FDA 9 Generic
  8. lamotrigine (Lamictal) : 1 outcome 1 study in 48 results : FDA 33 Generic
  9. Anti-Bacterial Agents (Antibiotics) : 1 outcome 1 study in 21 results : IBA
  10. Carboxymethylcellulose Sodium (Polycell) : 1 outcome 1 study in 4 results : FDA 2
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Diseases Related to Toxic Epidermal Necrolysis

  1. Stevens-Johnson Syndrome
  2. Graft vs Host Disease (Graft-Versus-Host Disease)
  3. Burns
  4. Skin Diseases
  5. Urticaria (Hives)
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Key Therapies for Toxic Epidermal Necrolysis

Efficacy Chart >>
  1. Plasmapheresis : 5 outcomes 3 studies in 18 results
  2. Plasma Exchange : 2 outcomes in 9 results
  3. Radiotherapy : 1 outcome in 21 results
  4. Transplantation (Transplant Recipients) : 1 outcome in 12 results
  5. Hemoperfusion : 1 outcome in 5 results
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